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Biochemistry & Molecular Biology

生物化学是细胞功能的分子基础的研究。它已演变成翻译分子生物学的进展到细胞和化学术语的共同语言。在生物化学和分子生物学系,我们研究范围广泛的细胞活动,从基因转录蛋白质,DNA,RNA和脂质膜的结构和功能。像所有的生物学家,我们尝试与相关成分的功能结构,但在细节的分子水平上,定义不仅管理功能的结构,而且还参与了化学反应。

生物化学领域汇集分子遗传学,细胞生物学的领域,并且每个这些标题可以被进一步细分为酶学的经典区域;结构和核酸蛋白质,碳水化合物和脂质的功能;代谢;和生物遗传学。

我们的教师为学生和博士后与研究经验的目的是了解基本的机制和细胞过程的结构基础。未来十年的发展将依赖于结构生物学,分子生物学和分子遗传学的混合物。我们整合的主题这些字段来自基因表达和染色质结构的调节,细胞信号传导,细胞周期控制,RNA和蛋白质的结构和功能,受体 - 配体或酶 - 底物相互作用跨度。我们利用原核,线虫和哺乳动物模型系统,并结合了先进的基因组学和蛋白质组学方法和仪器。我们鼓励您与我们联系,请访问我们的最先进的设施网站和状态,并了解更多有关的研究项目和研究生教育。

 

最新消息

  

Dr. Ruth Schwalbe

博士。露丝的Schwalbe由美国国立卫生研究院的研究获得了研究经费 N-聚糖上钾离子通道的作用。 三年, $ 438,010 美国国立卫生研究院资助 gm129679 重点是如何 在支化的N-聚糖结构的修改附接到kv3.1b 电压门控的K +通道 可以改变神经兴奋和机体的行为。她的研究可能 在改变神经电信号传输潜在地打开聚糖为基础的治疗选择的门

 

 

Keiper's Lab

Cold Spring Harbor Laboratories (CSHL) featured one of our own ag真人网赌平台 Biochem & Mol Biol PhD students, Mr. Hayden Huggins, in their online blog called 当前汇率”。 海登出席 生殖细胞 会议在长岛,纽约,与恺博实验室的其他成员一起。他从数百名学生,博士后和教师的调查中选择由冷泉港实验室出版物的工作人员。面试集中在他与DRS NSF资助的研究。恺博,并在生殖细胞发布会利,激动人心的发现,和他的职业生涯的方向。海登提出了题为“mRNA帽结合蛋白IFE-3是用于生殖细胞性别决定中。c关键。线虫”上5日会议的第2天海报。他的研究结果表明,卵母细胞和精母细胞选择一定的mRNA通过因子的eIF4E,蛋白质合成机器中从其中配子区分生殖细胞的一部分,以密封它们的发育命运。一年两次CSHL生殖细胞会汇集了来自世界各地的在人类,老鼠,苍蝇,鱼,蛙,蠕虫和其他几个模型系统的繁殖策略目前存在的分子和细胞生物学发现的科学家。你可以在阅读与海登完整的采访 当前汇率.

 

Dr. Brett Keiper

博士。布雷特恺博是由美国国家科学基金会,以研究蛋白质的合成生殖细胞和胚胎获得了研究经费。三年,$ 635,000 NSF资助的地址如何将新的蛋白质是由该细胞分化为胎儿发育和配子进行。实验将使用转基因线虫Ç(蠕虫)作为模型系统来定义的体内作用对mRNA翻译因子(eIF4E与eif4g)。最近已经加大了对RNA病毒的关注,如寨卡病毒能感染配子或胚胎,破坏基因调控,导致小头畸形等胎儿畸形。该项目涉及在林肯纪念堂大学合作。和ag真人网赌平台的部门内科,用进球发育缺陷以及生殖道癌和屏幕模型的方式来对待他们。

 

Dr. Tonya Zeczycki

博士。汤妮雅zeczycki收到$ 50,000,一年从美国帕金森氏病协会拨款,以研究如何α-突触核蛋白,负责的帕金森病患者的大脑斑块形成的蛋白质的构象由转谷氨酰胺酶2的翻译后修饰后改变通过这个基金的支持将重点放在确定为什么一些修改,促进蛋白质的聚集和斑块形成,而另一些保护,或抗聚集,影响了研究。她的研究可能会导致新的和听话的疗法是力α-突触核蛋白采用累积总无能构象。

 

Nate Fry

纳撒尼尔(奈特)炒,博士研究生博士的实验室。凯尔曼斯菲尔德,近日发表了一篇题为“N6甲基腺苷需要特定mRNA的缺氧稳定”这是对期刊RNA的盖突出的文章。  Nate&#’;sNate&#’;shaniel (Nate&#’;s) Fry, a PhD graduate student in the laboratory of Dr. Kyle Mansfield, recently published an article entitled “N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs” that was highlighted on the cover of the journal RNA.<span>  </span>Holley&#’;sNate&#’;s</p><p> </p></div></div></td></tr></tbody></table></div><div class="cs_control CS_Element_TAI" id="cs_control_940600"><table class="clsControlBorder CS_FullWidth CS_TableNoBorder CS_TableNoBorderSpacing CS_TableNoPadding"> <tbody><tr><td class="CS_FullWidth CS_VAlignTop CS_AlignLeft"><div class="CS_TAI_Text"><img alt="Matthew MacDougall" class="CS_TAI_Image CS_FloatRight" height="135" src="/cs-dhs/biochemistry/images/MACDOUGALL_1.jpg" title="" width="100"/><div class="CS_AlignLeft CS_TAI_Text"><p>Matthew R. MacDougall, of Dr. Myles Cabot’s lab, East Carolina Diabetes and Obesity Institute, and the Department of Biochemistry & Molecular Biology, Brody School of Medicine, presented a talk, entitled “Alterations in Sphingolipid Metabolism Attribute to Resistance to Cornerstone AML Therapies” on September 10, 2017, at the XII International meeting of the Sphingolipid Club (SLC), Trabia (Sicily, Italy). The SLC was founded in October 2001, by a group of Italian scientists with the idea to bring together researchers interested in sphingolipid biology, biochemistry, chemistry, pathophysiology, and clinical aspects. The meeting has since grown in breadth and scope and is now attended by scientists and physicians from around the world. For his talk, Matthew received a Young Scientist Award, which was especially notable, as he was in competition with PhD students and postdoctoral scholars. Mathew has a BS degree in Chemistry from UNC, Pembroke, and has been working in Cabot’s lab since 2014, collaborating with groups at UVA Cancer Center and Penn State Hershey Cancer Center, on chemotherapy resistance in AML (acute myeloid leukemia). 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